Ethanol Induced Metabolic Alterations and the Effect of Phyllanthus Niruri in Their Reversal

نویسندگان

  • D. Umarani
  • T. Devaki
  • P. Govindaraju
  • K. Radha Shanmugasundaram
چکیده

Phyllanthus niruri, Linn. (Kizha nelli in Tamil and Bahupatra and Bhumyamlaki in Sanskrit) which has been used widely for liver afflictions, was tried for its effectiveness in ethanol induced fatty liver, developed in rats, the increased deposition of triglyceride, cholesterol and phospholipid found in the liver, brain, kidney and heart due to ethanol administration were brought back towards the normal values on the administration of the herbal powder, however, in the intestine and stomach the increased ATPase activity observed due to alcohol ingestion, was only partially reduced.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluation of hair growth promoting activity of Phyllanthus niruri

Objectives: This study was designed to investigate the potential Phyllanthus niruri extracts in promotion of hair growth. Materials and Methods: Here, we studied the hair growth promoting activity of petroleum ether extract of P. niruri following its topical administration. Alopecia was induced in albino rats by subcutaneous administration of testosterone for 21 days. Evaluation of hair loss in...

متن کامل

Gene expression profiling reveals underlying molecular mechanism of hepatoprotective effect of Phyllanthus niruri on thioacetamide-induced hepatotoxicity in Sprague Dawley rats

BACKGROUND The liver plays an essential role in the body by regulating several important metabolic functions. Liver injury is associated with the distortion of these functions causing many health problems. Pharmaceutical drugs treat liver disorders but cause further damage to it. Hence, herbal drugs are used worldwide and are becoming increasingly popular. METHODS The hepatoprotective activit...

متن کامل

Characterization of Metabolite Profile in Phyllanthus niruri and Correlation with Bioactivity Elucidated by Nuclear Magnetic Resonance Based Metabolomics.

Phyllanthus niruri is an important medicinal plant. To standardize the extract and guarantee its maximum benefit, processing methods optimization ought to be amenable and beneficial. Herein, three dried P. niruri samples, air (AD), freeze (FD) and oven (OD), extracted with various ethanol to water ratios (0%, 50%, 70%, 80% and 100%) were evaluated for their metabolite changes using proton nucle...

متن کامل

Gastroprotective effect of Phyllanthus niruri leaf extract against ethanol-induced gastric mucosal injury in rats

The main objective of this study is to evaluate the gastroprotective activity of the Phyllanthus niruri leaf extract against ethanol-induced gastric mucosal injury in rats. Six groups of Wistar rats were pretreated, respectively, with distilled water; omeprazole 20 mg/kg; and 250, 500, 750 and 1000 mg/kg P. niruri leaf extract 30 min before oral administration of absolute ethanol to generate ga...

متن کامل

Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L. (Euphorbiaceae) leaves in experimental rats

BACKGROUND The medicinal plants signify a massive basin of potential phytoconstituents that could be valuable as a substitute to allopathic drugs or considered as an analogue in drug development. Phyllanthus niruri L. (Euphorbiaceae) is generally used in traditional medicine to treat ulcer and inflammation. In this project we investigated the methanolic extract of leaves of Phyllanthus niruri f...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 4  شماره 

صفحات  -

تاریخ انتشار 1985